Desmond Tobin

Centre for Skin Sciences, University of Bradford, United Kingdom

Professor of Cell Biology, Department of Biomedical Sciences, University of Bradford.

BSc. in Biology, Chemistry & Math (1986), National University of Ireland-Maynooth; GIBiol. in Immunology (1987); Ph.D. in Dermatopathology (1991), University of London (St. Thomas’s Hospital Medical School/St. John’s Institute of Dermatology); Post-Doctoral Fellow at NYU Medical Center - Dept. of Dermatology (1991-1993); Assistant Research Professor in Dermatology, NYU Medical Center - Dept. of Dermatology (1993-1996); Associate Professor in Cell Biology (2002-2004).

Fellow of Institute of Biology (UK), Fellow of Institute of Trichologists (UK), Member of Royal College of Pathologists (UK), Member of Society of Investigative Dermatology, Member of European Society for Pigment Cell Research, Member of European Hair Research Society (amongst others).

Research Interests: Regulation of skin and hair follicle melanocyte biology, especially with regard to neuroendocrine controls and aging influences. Elucidation of etiology and pathomechanisms of immune-mediated hair loss, particularly alopecia areata. Regulation of hair growth and cycling, especially with regard to mesenchymal cell dynamics.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Dermatology > Pigmentary Disorders (since 28 March 2006)

Links

http://www.brad.ac.uk/acad/biomed/STAFF/CORE/TOBIN.html

All recent recommendations

• 9.0
  Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.
  Recommended by Desmond Tobin
  
• 8.0
  Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
  Recommended by Ralf Paus with Elisabeth Gaspar, Jennifer Klatte, Stephan Tiede, Burkhard Poeggeler, Desmond Tobin
  
• 6.0
  Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence.
  Recommended by Desmond Tobin
  
• 6.0
  Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis.
  Recommended by Desmond Tobin
  
• 3.0
  BMP-4 upregulates Kit expression in mouse melanoblasts prior to the Kit-dependent cycle of melanogenesis.
  Recommended by Desmond Tobin
  
• 6.0
  Recent Trends in Incidence of Cutaneous Melanoma among US Caucasian Young Adults.
  Recommended by Desmond Tobin
  
• 3.0
  In vitro expansion of immature melanoblasts and their ability to repopulate melanocyte stem cells in the hair follicle.
  Recommended by Desmond Tobin
  
• 6.0
  Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes.
  Recommended by Desmond Tobin
  
• 3.0
  Quantification of Ca(2+) binding to melanin supports the hypothesis that melanosomes serve a functional role in regulating calcium homeostasis.
  Recommended by Desmond Tobin
  
• 3.0
  Membrane lipid alterations as a possible basis for melanocyte degeneration in vitiligo.
  Recommended by Desmond Tobin
  
• 6.0
  Cannabinoid receptors as novel targets for the treatment of melanoma.
  Recommended by Desmond Tobin
  
• 3.0
  sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism.
  Recommended by Desmond Tobin
  
• 6.0
  Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity.
  Recommended by Desmond Tobin
  
• 6.0
  Melanoma, a tumor based on a mutant stem cell?
  Recommended by Desmond Tobin
  
• 6.0
  CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH.
  Recommended by Desmond Tobin