Holden Maecker

School of Medicine, Stanford University Medical Center, USA

Holden Maecker is director of the Human Immune Monitoring Center at Stanford University, and is a consultant in the field of flow cytometry. His research interests include the development and function of T cell responses to cancer and pathogens such as HIV, CMV, and tuberculosis, with a goal of defining cellular correlates of immune protection for these diseases.Holden received his Ph.D. from Stanford University, where he also did postdoctoral work. He has previously held positions at Loyola University Chicago and BD Biosciences, San Jose, CA.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Infectious Diseases > HIV Infection & AIDS: Basic Science (since 26 March 2008)

All recent recommendations

• 3.0
  CD45RA expression on HCMV-specific effector memory CD8+ T cells is associated with the duration and intensity of HCMV replication after transplantation.
  Recommended by Holden Maecker
  
• 3.0
  Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.
  Recommended by Holden Maecker
  
• 3.0
  Cutting Edge: Memory CD8 T Cell Compartment Grows in Size with Immunological Experience but Nevertheless Can Lose Function.
  Recommended by Holden Maecker
  
• 3.0
  High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40).
  Recommended by Holden Maecker
  
• 3.0
  Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV suppressive activity.
  Recommended by Holden Maecker
  
• 8.0
  Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.
  Recommended by Holden Maecker, Sheena McCormack with Sarah Joseph
  
• 3.0
  Magnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical status.
  Recommended by Holden Maecker
  
• 3.0
  No major differences in the functional profile of HIV Gag and Nef-specific CD8+ responses between long-term nonprogressors and typical progressors.
  Recommended by Holden Maecker
  
• 3.0
  Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
  Recommended by Holden Maecker
  
• 3.2
  Central memory CD8(+) T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.
  Recommended by Holden Maecker, Guido Silvestri
  
• 8.2
  Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.
  Recommended by Ann Duerr, Paul Goepfert with Anju Bansal, Holden Maecker with Laurel Nomura
  
• 3.0
  HLA Class I-Restricted T Cell Responses May Contribute to the Control of HIV Infection, but Such Responses are Not Always Necessary for Long-term Virus Control.
  Recommended by Holden Maecker